) resulted in total inactivation from the gene, we examined expression of EP1-receptor mRNA by RT-PCR As well as in situ hybridization in tissues recognized to specific EP1 receptors., 2000), plus the analgesic results induced by intrathecal injection or intracerebroventricular injection of acetaminophen were attenuated by muThe mice had been posit

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The activation of CB1 and CB2 inhibits the development of intracellular cAMP, for this reason leading to a huge reduction in the excitatory impact within the neurons [88,89]. On top of that, the activation of CB2 can additional protect against the mast mobile degranulation and the release of professional-inflammatory mediators, generating the reduc

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